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Hello, this is Dr. Bob
Wildin, I am your instructor.

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No longer Tamara Williams,

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at least for this module.

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And I'm giving your
introduction to module 5.

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So module 5 is about
beginning to translate

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that basic genetics
and biology information

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that we've been learning
about for several modules

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into something that we
actually use in the clinic.

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And the topics for this module

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are about genetic change, mutations,

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and how they cause phenotypes.

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The sets of features that we describe

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in patients with genetic disorders.

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It's about simple patterns of inheritance,

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so-called Mendelian inheritance,

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those that were described and
explained by Gregor Mendel.

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And about using family history

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and the tool that we use to

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sort of shorthand for family
history, the pedigree,

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in relation to Mendelian
patterns of inheritance.

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So, we really are sort
of pulling along with us

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on that knowledge of the basic genetics

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and the mechanisms of gene
expression and translation

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to began to apply it really
to things in the clinic.

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Now, we delved into that
a little bit last week

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in the discussion board exercise.

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And I thought that was
really fun and productive.

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You guys did great.

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And I want to sort of
continue that in this module.

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So, there are two lectures
by Tamara Williams,

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and then one by me about making pedigrees.

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And we'll just sort of jump ahead

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and let you know that

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from next week, we'll
continue this overall theme,

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but we're going to be talking about other

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more complex imperatives,

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problems, and more complex ways

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to represent more complex situations

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in the pedigree as well.

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So, for this week, in addition
to the three lectures,

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you have corresponding reading
assignments in the book,

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and then also a required exploration

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of a great, great web resource,
Genetics Home Reference,

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which we also touched on last week

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in the discussion board exercise.

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But this time, we have a
complete walkthrough video

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by Tamara Williams.

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Now, you'll notice that
the video that she made

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was at a time when the look
and feel of the website

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was a little different.

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But rest assured that the content,

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the basic navigation,

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and the organization of the information

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is really entirely the
same as it was then.

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So don't get put off by that.

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You have an assignment,

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which consists of three case studies.

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And you can use Genetics Home Reference

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or other similar authoritative
source to help answer those.

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The level of detail in your answers

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does not to need to be extensive,

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but it does need to be sufficient

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to really answer those questions.

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If you want to see how your answers feel

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to people who are non-medical,

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pick some out of your friends or family

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and try them out on
those willing subjects.

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Discussion board this
week is self-explanatory.

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It's a pretty busy week,

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so please try to keep things succinct.

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And remember that there is a Q&A board

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still there this week for
any questions you may have.

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Finally, there is, of
course, a required quiz.

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So, I'm really excited to be moving more

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into the clinical domain

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and starting to meld those basic knowledge

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that we've been developing

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into talking about genetic
diseases, about inheritance,

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and also some of the tools that we use

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in the clinic on a regular basis

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to try to understand what's going on.

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So, I look forward to a great week,

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and thank you for now.