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Hi there. Welcome to module three.

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So in this week we're going
to dive a little bit deeper

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into some of the molecular genetics,

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but really again, just kind
of hitting the high notes

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of what's really the most
important for you to know

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to then translate this
into clinical applications

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and a really strong foundation in genetics

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that you can use in the clinical context

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and in talking with patients.

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So this week we're going to
talk about gene expression

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and regulation of gene expression,

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DNA replication, and mitosis and meiosis.

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So this is actually
pretty full week, okay?

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So just so you know, ahead of time,

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there's a lot going on this week.

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We've kind of warmed
up with the first week

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and the second week you really got started

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to get into the material,

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become a little familiar with it.

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Now we're really going to
dive right into the heart

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of the material.

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So there's quite a bit to cover
this week, but not to worry.

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I have every confidence
you'll do a great job with it.

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And yeah, I look forward
to getting your questions

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and discussions going about it.

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So don't hesitate if you
have questions on anything,

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please post to the discussion
board and let me know

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and, you know, we'll
clarify it from there.

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So there are three lectures
that are posted for this week

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and the first one that I posted

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is gene expression and regulation.

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That one's a pretty long
one, that's pretty long.

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It's about an hour long,
just under an hour long

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for the lecture itself.

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It's kind of a, a new concept

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if you're not familiar
with molecular biology

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or cell biology.

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So I wanted to explain it in
a number of different ways.

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If you're really familiar
with these topics,

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you may be able to kind of
breeze through it a bit,

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but I wanted to err on the side

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of giving you more information

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and more ways of learning
it than, than less.

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So that one's about an hour long.

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Then the next one I have
posted is a short one,

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just to give you a break
after that first long one,

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which is DNA replication.

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So the process of basically
duplicating the entire genome

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in preparation for a cell to divide.

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So that's a separate lecture

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and that's just under 10 minutes long.

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And then the third and final
lecture for this module

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is going to be on mitosis and meiosis,

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which are the two
processes of cell division.

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One, which is basically to
create two identical cells,

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two cells that are identical to the cell

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that started the division.

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Meiosis being the process of
creating egg or sperm cells.

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And those are not identical
to the starting cell,

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but instead they have half
the number of chromosomes.

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So we know we have what we
call 23 pairs of chromosomes,

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22 autosomes, and then a
pair of sex chromosomes,

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which is either two X
chromosomes for female

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or one X and one Y if you're male

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and gametes, which are egg or sperm cells,

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they have only one copy of each, right?

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Because that way when they fuse together,

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when one egg and one sperm fuse together,

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you end up with a pair

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of each of each chromosome, right?

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So then you end up with a
total of 46 chromosomes.

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So there has to be a process in place,

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a really careful, precisely
regulated process in place

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to make sure that our
gametes are formed properly

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and that they get the right
number of chromosomes,

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that they have one of
each kind of chromosome

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found in the gamete

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and exactly one in order to
maintain the correct number

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of chromosomes in our genome
from generation to generation.

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So that process is meiosis.

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All right, so I have a lecture on that,

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that's about 25 minutes long

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and that's the third and
final lecture in this week.

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So I have the PowerPoints
for each of those as well.

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In the required reading,

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you have a few more pages

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to finish out that chapter
four in your textbook.

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If you still don't have the textbook,

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you can go back to module two

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where the whole chapter
four was scanned in

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and just read the pages that
are assigned for this week.

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I have an excerpt from the
chapter that I wrote in genetics

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that I think, you know, can
maybe just give you another way,

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another perspective on how to understand

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the same kind of material.

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So that's there and it goes
in a little more detail

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than what you get in the textbook.

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And then I have a folder

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with some links to some animations

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of some of these central concepts
that we're talking about.

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I find it really helpful
as more of a visual learner

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to see things drawn out for me

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and actually see animations where possible

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of these molecular
events that are going on

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because otherwise they seem so,

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they can seem so abstract.

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To actually put pictures down

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and say, okay, you know, this
goes here, this goes there

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and then this happens,

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to me, that can be a
little bit more intuitive.

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And so if that's your
preferred learning style

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or something that might
be beneficial to you,

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please go through those animations
I've given you links to.

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If you feel like you really
have the concepts down,

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I mean, you don't have to use those,

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those are just a resource
there for you to, again,

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have another way of another teaching style

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or learning style that might
be a better fit for you

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or might be complimentary
to the way that you learn.

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Okay, what else?

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Well, we have our usual quiz

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and that you, again, as always

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can take up to three times.

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And look out for, remember,

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read each question carefully please,

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because some of them, it's
select all that applies.

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Some of them it's just
select the best answer.

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So make sure you read the
text of the question carefully

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so that you know what
type of question it is.

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There's an assignment
and that is posted up.

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It's a series of questions
that I'm asking you

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to write out an answer for each

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and then upload that back as
a Word document if possible.

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It's easier for me if you can turn it in,

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submit it back as a Word document

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and not like a PDF or something

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that I can't really add notes to

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because it's easier for
me in a Word document

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to go back and, you know, add
notes and comments to you.

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And then I'll post that
back to the assignment page

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once it's been graded with my notes on it.

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There's a discussion board post

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that I'd ask you to make with a prompt.

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And then of course the
discussion board forum

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where you can post any
questions that come up for you

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as you're going through the material.

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Please don't hesitate to post those

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because it gives me a chance

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to know where you maybe

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could use a little more
clarification, a little more time

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because unfortunately we
don't have the benefit

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of being face-to-face.

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It's hard for me sometimes to get feedback

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to know what areas you might
need a little more help in

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or I could do maybe a
better job of explaining

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or give you some more resources for that.

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So please don't hesitate
to post those questions

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and I'll do my best to answer
them as quickly as possible.

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And also don't hesitate
to chime in as well

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if you have some thoughts

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on a question that someone has posted.

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Okay, I think that might be it.

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So for this week, I will leave you to it

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and as always, I'm available

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if there's anything I can do to help

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in this week's material.

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But otherwise, I look
forward to reading your posts

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and getting discussion going

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on the discussion board this week.

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Take care. Bye.