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Welcome to module 11,

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in this module, we're
going to discuss cancer.

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And you may wonder why would we spend

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so much time talking
about cancer specifically?

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Well, cancer is actually the
most common genetic disease,

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and we're going to discuss
it really from that context,

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as well as understanding,

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so basically understanding

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how genetics plays a role in this.

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And by that I don't just
mean inheriting a risk

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for cancer, that's certainly a part of it,

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but also how we develop cancer

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by accumulating mutations
in our genomes over time

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in different cells in our body.

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And that is the influence

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of the environment
around us, our lifestyle,

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what we can do to reduce those risks

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to developing cancer in the future.

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So there are two lectures this week,

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and the first one is a pretty long one,

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but hopefully, you give
me a little slack on that

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because cancer is a
challenging topic to discuss.

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It can be quite complicated.

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In fact, many people spend
their entire careers focusing

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only on trying to understand
one teeny tiny piece

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of an enormous picture
that is cancer biology.

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So I condensed it down as much

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as I reasonably thought I could

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to give you a solid foundation

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and understanding in
it, fully acknowledging

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that you may not practice
in oncology at all,

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but I can almost guarantee
everyone's life has been affected

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in one way or another by cancer.

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And certainly that will be the case

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for probably a good
portion of the patients

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who come through your door.

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And so understanding the
molecular mechanisms,

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at least from a high level for cancer,

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I feel like is a good use of our time.

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And again, since it is the
most common genetic disease,

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it clearly has an important
role for this course.

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The second lecture is half that time,

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so that's good is is about half an hour

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and that is focusing on
targeted therapeutics.

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So taking it the next step,

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so the first lecture is
really in the fundamentals

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of cancer biology, how
cancer forms and develops

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and then the second lecture
is more focusing on some

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of these new targeted therapeutics

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that are designed at a molecular level

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to specifically target cancer cells,

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to destroy those cells,
to prevent cancer growth

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or to assist in the
success of a therapeutic,

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another therapeutic regimen
that goes along with that one.

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And talking about why it is

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that pharmaceutical
companies in particular

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are quite interested

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in developing these targeted therapeutics

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and the potential benefits
of them in the long run.

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I'm putting in the context of cancer here,

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but it can certainly be applied

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and would be applied

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to other disease states as well

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where there potentially
is a specific target.

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And if you think back

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to last week when we're talking
about autoimmune conditions,

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for example, this may
lend itself some of these,

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the concepts of targeted therapeutics

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may lend themselves well the future

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to targeting autoimmune disorders

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for more successful treatment there,

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so those are the lectures.

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There's a chapter in your textbook

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that I'm asking you to
read as well as an excerpt

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from the genetics chapter
that I had written,

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that's just the excerpt
that's related to cancer.

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And then I have a quick...

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It's sort of like a pamphlet
that's in a PDF format

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that came out from, I
think it was from the not

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that's from the Department of Vermont,

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State Department of Health.

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I'm not exactly sure who put it out,

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but it's basically focused on melanoma

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in the state of Vermont.

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Melanoma is a huge risk to those

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who live in the state of Vermont.

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We have one of the
highest rates of melanoma

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and highest rates of death,
melanoma of really any state.

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And it talks a little
bit about why that is

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and, you know, it's very re
reader friendly approach...

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It's just a really a
public health bulletin,

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so that's there for you to
read as it applies to you,

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your practice in Vermont and
also for you living in Vermont.

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And then there's also another PDF

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sort of a another pamphlet
type of type of thing.

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It's was put out by the
American Cancer Society

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and it's not required reading,

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but it, especially if you're
really interested in learning

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more or if you have have
patients in your practice

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that have cancer or you
yourself are just interested

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in reading more about it,

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that's a really nice summary document.

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It's about 15 pages.

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Again, not required for you to read it,

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but I think it's a really good resource.

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If nothing else, just
download it on your computer,

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save it for maybe sometime in the future

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when you might need it or
might wanna reference it again,

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so that's there.

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And then you have quiz this week

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and the assignment this week,

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there's actually three parts to it.

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The first part is, and
it's all in one document,

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so you'll open it up

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and it'll say part one,
part two, part three

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and the first part is
just some basic questions

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around the biology of cancer.

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Just a, a refresher

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to make sure you're
understanding the concepts

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from the lectures and the reading.

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And the second part is

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some quick case study questions

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just to try to put it into the context...

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Taking the biology,

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and put it in the context of practice.

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And then the third part
I'm asking you to do,

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just to make sure we're
all getting on track

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with doing the final project,

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which is actually not that far away,

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and as the semester's somehow starting

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to come to a close already.

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So I wanted to make sure
everyone was starting

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to think about your final project.

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And as such, the third
part of the assignment

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for this week is really just for you

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to write into in the assignment document

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which condition or disease
you're planning to focus on

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for your final project

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And it doesn't have to be...

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You're not a hundred
percent locked into that,

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it's just so that I have a sense of

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where you might be going with it.

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It also gives you a
chance to, if you want,

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if you have any questions
about the final project

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to put those in there

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and I'll get you feedback on that as well.

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You can always email
me with questions too,

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but this way it gives you,
it gives you an assignment

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to do this now.

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So your mind is at least
starting to really think about

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what you're going to do
for your final project

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and making sure that
everyone has taken a look

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at what the requirements
are for this paper

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and there's two parts to it, right.

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So there's the paper,
which is the main part,

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then there's also the
collection of resources

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that you could pull up

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and hopefully you've collected some

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over the semester anyway,
it's just putting it into more

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of an organized format where
I'm asking you to just include

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most likely a list of websites

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and other resources

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that you think could
be helpful potentially

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in your practice

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or your future practice.

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So that's there again,

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simply so that when you
walk away from this course,

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you have something in your hands.

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It's not, oh, what was that six months ago

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when I was taking that course

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with ]that crazy lady who
made all those weird videos?

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What was that?

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What was that website

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that I went to that was really helpful.

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I only I could remember, oh
wait, I don't have to remember

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because it's on the list

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that I created for my final
project, that's the goal.

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So if you could assemble that

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and so maybe start thinking about that.

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Put some together of
what you've already found

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as being helpful

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and it's just gonna be
like a bullet point list

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of 10 resources that you,

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at least 10 you know more if you have more

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that are helpful websites

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that you've found to be useful

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or could be useful for you in the future.

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Okay, I think that
pretty much wraps it up.

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There's the discussion board, of course,

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and I look forward, you know,

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to talking with you some more
about the cancer biology,

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targeted therapeutics and anything else

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that comes up to mind this week.

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So I think with that, I
will close out for now

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and wish you a happy April.

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And yeah, again, as always,

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let me know if you have
questions on anything

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and I will get back to
you as soon as I can,

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thanks very much, bye-bye.