1 00:00:00,690 --> 00:00:03,270 Hello, I'm Dr. Bob Wildon. 2 00:00:03,270 --> 00:00:07,830 I'm a medical geneticist and I am the course director 3 00:00:07,830 --> 00:00:11,970 and instructor for your course Genetics for Clinicians, 4 00:00:11,970 --> 00:00:16,083 also known as GNRS 325 or PATH 325. 5 00:00:17,790 --> 00:00:21,000 I am an associate professor of pathology 6 00:00:21,000 --> 00:00:24,240 and laboratory medicine and pediatrics in genetics 7 00:00:24,240 --> 00:00:26,940 at the University of Vermont Health Network 8 00:00:26,940 --> 00:00:29,103 and the medical school. 9 00:00:30,000 --> 00:00:32,160 I am board certified in pediatrics 10 00:00:32,160 --> 00:00:34,110 and also in medical genetics 11 00:00:34,110 --> 00:00:36,183 in the specialty of clinical genetics. 12 00:00:37,230 --> 00:00:39,480 So I wanted to give this kind of introduction to myself 13 00:00:39,480 --> 00:00:43,379 so you'll understand my background 14 00:00:43,379 --> 00:00:44,940 in teaching this course 15 00:00:44,940 --> 00:00:46,840 that you're just about to embark onto. 16 00:00:47,790 --> 00:00:48,780 So how did I get here? 17 00:00:48,780 --> 00:00:53,780 I did my undergraduate degree at MIT in life sciences 18 00:00:54,180 --> 00:00:57,360 and I went to medical school 19 00:00:57,360 --> 00:01:00,547 at the University of California in San Francisco. 20 00:01:00,547 --> 00:01:03,939 I participated in research and research labs 21 00:01:03,939 --> 00:01:06,670 both on the undergraduate and the graduate level 22 00:01:07,590 --> 00:01:12,590 and then finally went to residency in pediatrics 23 00:01:12,870 --> 00:01:15,060 at the University of Washington. 24 00:01:15,060 --> 00:01:17,550 I followed that with a fellowship in medical genetics 25 00:01:17,550 --> 00:01:20,010 and molecular immunology at the University of Washington 26 00:01:20,010 --> 00:01:21,663 as well in Seattle. 27 00:01:22,980 --> 00:01:25,170 I started on the faculty at the University of Washington 28 00:01:25,170 --> 00:01:27,900 in pediatrics and then moved to a faculty position 29 00:01:27,900 --> 00:01:31,170 at UT Medical Branch in Galveston, Texas 30 00:01:31,170 --> 00:01:35,640 and finally to Oregon Health Sciences University. 31 00:01:35,640 --> 00:01:37,800 There, I saw patients 32 00:01:37,800 --> 00:01:39,450 and also did a fair amount of research. 33 00:01:39,450 --> 00:01:42,630 I studied a genetic endocrine and kidney disorder 34 00:01:42,630 --> 00:01:45,420 called nephrogenic diabetes insipidus. 35 00:01:45,420 --> 00:01:47,594 I also did a research 36 00:01:47,594 --> 00:01:51,390 that defined a rare genetic disease called IPEX 37 00:01:51,390 --> 00:01:53,790 and laid the theoretical foundation 38 00:01:53,790 --> 00:01:55,540 for gene therapy in that condition. 39 00:01:56,610 --> 00:01:58,290 Come full circle, I currently serve 40 00:01:58,290 --> 00:02:01,110 on the FDA Data Safety Monitoring Committee 41 00:02:01,110 --> 00:02:03,990 for a gene therapy clinical trial for that disorder 42 00:02:03,990 --> 00:02:05,193 I'm very excited about. 43 00:02:06,480 --> 00:02:09,240 I carried that research from OHSU 44 00:02:09,240 --> 00:02:12,228 to the Pastor Institute in Paris, France, 45 00:02:12,228 --> 00:02:16,030 where I worked on sabbatical for a year 46 00:02:17,520 --> 00:02:21,240 and went back to Oregon and became an independent geneticist 47 00:02:21,240 --> 00:02:24,090 for community-based healthcare organizations 48 00:02:24,090 --> 00:02:27,540 and started the first genetics clinics at such organizations 49 00:02:27,540 --> 00:02:30,633 in Oregon, Idaho, and later in Virginia. 50 00:02:33,600 --> 00:02:35,220 I took a job then 51 00:02:35,220 --> 00:02:37,680 at the National Human Genome Research Institute 52 00:02:37,680 --> 00:02:40,410 at the NIH in Bethesda, Maryland. 53 00:02:40,410 --> 00:02:43,230 My title was Chief of the Genomic Healthcare Branch, 54 00:02:43,230 --> 00:02:45,690 which basically involved promoting the integration 55 00:02:45,690 --> 00:02:49,680 of genomic science that was being funded by NIH 56 00:02:49,680 --> 00:02:53,913 into mainstream medical practice in the community at large. 57 00:02:55,410 --> 00:02:58,814 And two large portions of my portfolio included 58 00:02:58,814 --> 00:03:01,650 healthcare, professional education and genetics 59 00:03:01,650 --> 00:03:06,513 and genomics and family health history. 60 00:03:07,950 --> 00:03:11,794 In 2017, I moved to the University of Vermont, 61 00:03:11,794 --> 00:03:15,330 where I wear multiple hats. 62 00:03:15,330 --> 00:03:18,333 I see patients in the clinic and in the hospital. 63 00:03:19,980 --> 00:03:21,990 And my clinic day is on Mondays 64 00:03:21,990 --> 00:03:25,320 and I'm pretty focused on the clinic patients on Mondays 65 00:03:25,320 --> 00:03:27,690 so I'm not very available to respond 66 00:03:27,690 --> 00:03:31,020 to email questions relating to the course. 67 00:03:31,020 --> 00:03:32,310 So if you have a question on Monday 68 00:03:32,310 --> 00:03:36,990 and you need a quick answer, either ask your fellow students 69 00:03:36,990 --> 00:03:39,150 through the discussion board 70 00:03:39,150 --> 00:03:43,650 or reach out to Professor Shukla, my co-instructor, 71 00:03:43,650 --> 00:03:45,630 and she may be able to help you. 72 00:03:45,630 --> 00:03:48,420 Otherwise, I'll try to respond to your questions 73 00:03:48,420 --> 00:03:51,153 as soon as I'm able on Tuesday. 74 00:03:53,100 --> 00:03:55,230 I also work... 75 00:03:55,230 --> 00:03:57,120 Three quarters of my job is in the 76 00:03:57,120 --> 00:03:58,830 hospital genomic medicine laboratory 77 00:03:58,830 --> 00:04:01,440 where I'm Associate Medical Director. 78 00:04:01,440 --> 00:04:05,130 I sign out reports from sequencing of tumor DNA 79 00:04:05,130 --> 00:04:07,710 for precision oncology therapy. 80 00:04:07,710 --> 00:04:10,290 I also lead efforts to introduce pharmacogenomic testing 81 00:04:10,290 --> 00:04:12,180 across the health network, 82 00:04:12,180 --> 00:04:15,843 and I lead the Network's Genomic Population Health program, 83 00:04:16,770 --> 00:04:20,460 which basically is a partnership 84 00:04:20,460 --> 00:04:25,313 with primary care physicians to offer genetic testing 85 00:04:26,310 --> 00:04:28,200 for hidden health risks 86 00:04:28,200 --> 00:04:31,380 that may impact their health care in the future 87 00:04:31,380 --> 00:04:34,683 or their propensity to have children with genetic disorders. 88 00:04:36,540 --> 00:04:40,803 I've published two papers on that program in the last year. 89 00:04:43,470 --> 00:04:45,120 I also do education. 90 00:04:45,120 --> 00:04:47,850 I teach graduate students like yourselves, 91 00:04:47,850 --> 00:04:49,140 medical students, residents, 92 00:04:49,140 --> 00:04:53,790 and fellows about genetics and genomics. 93 00:04:53,790 --> 00:04:55,890 I do original research and data analysis 94 00:04:55,890 --> 00:04:58,563 regarding the genomic population health program. 95 00:05:01,440 --> 00:05:04,050 I am passionate about using genetic information 96 00:05:04,050 --> 00:05:06,360 to improve health and wellbeing, 97 00:05:06,360 --> 00:05:10,110 and I really enjoy working with data, organizing it, 98 00:05:10,110 --> 00:05:13,593 and analyzing it for new insights. 99 00:05:14,760 --> 00:05:17,490 And I'm also passionate about educating the next generation 100 00:05:17,490 --> 00:05:19,740 of healthcare professionals like yourselves 101 00:05:19,740 --> 00:05:22,200 about genetics and genomics. 102 00:05:22,200 --> 00:05:25,230 Personally, I live near Burlington with my husband, 103 00:05:25,230 --> 00:05:27,390 with whom I've been together for 22 years, 104 00:05:27,390 --> 00:05:29,400 and we don't have any pets. 105 00:05:29,400 --> 00:05:31,440 I do enjoy photography, gardening, 106 00:05:31,440 --> 00:05:33,243 and the occasional acrylic painting. 107 00:05:35,610 --> 00:05:38,340 So that's the end of my self-introduction. 108 00:05:38,340 --> 00:05:42,150 I look forward to working with you all 109 00:05:42,150 --> 00:05:43,590 through this semester 110 00:05:43,590 --> 00:05:46,110 and helping you add an additional facet 111 00:05:46,110 --> 00:05:49,770 to your healthcare professional expertise. 112 00:05:49,770 --> 00:05:52,263 Take care and good luck.